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In the human appendix there is always a neuroendocrine tumor (NET) with similar development to carcinoid. It has been postulated that pathological vascularization of the appendix may be due to the action of angiogenic factors, particularly VEGF and that inhibition of the production of such factors may represent a potentially useful therapy. The expression of VEGF-A, VEGF-C, VEGF-D, VEGF-receptor 2 (VEGFR-2) and the metalloproteinases MMP-1, MMP-2, MMP-9, MMP-14 and MT1-MMP were studied in normal appendix and in the NET of the appendix. In the NET, expressions of VEGF-A, VEGF-C, VEGF-D, MMP-2, MMP-9 and MT1-MMP were stronger than in the normal appendix. MMP-14 was also increased, but this difference was not significant. MMP-1 and VEGFR-2 were increased in the NET as compared to the normal appendix, but this difference was significant only for MMP-1. It is concluded that vascularization of neuroendocrine tumors of the appendix is mediated, at least partially, by the production of angiogenic factors, and that the inhibition of the production of these factors might be a potential therapeutic strategy.Protecting the privacy of women in the United States has become a grave concern and an issue of great importance to the lesbian, gay, bisexual, and transgender (LGBT) community, including men. LGBT men have a unique visibility issue of their own as men who have sex with men (MSM). This project seeks to develop the design and conduct of a nation-wide survey to assess LGBT men’s experiences

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