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2pac Discography (1991-2007).zip
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Major histocompatibility complex (MHC) class I proteins have a unique structure and function: they are transported from the endoplasmic reticulum and the Golgi apparatus to the surface of cells via the secretory pathway in association with class II molecules. An integral membrane component of this class II-class I complex is encoded by exon 9 of the class I heavy chain gene. Here we report that the mRNAs encoding the entire 3′-untranslated region (UTR) of class I heavy chain transcripts are expressed in the endoplasmic reticulum and Golgi apparatus of primate cells and in all mouse tissues examined. Cells depleted of the 3′-UTR were unable to transport MHC class I molecules to the plasma membrane. Thus the entire 3′-UTR is essential for protein synthesis, transport, and cell surface expression.Plectranthus asperatus
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